Under mixing ventilation, CO 2 sensors placed at the room exhaust can meet the requirements of sensor accuracy defined by ASTM E741 and California Title 24. The results show that the ventilation strategy, occupancy level, and air change rate have notable impacts on the CO 2 sensing performance. Experimentally validated computational fluid dynamics (CFD) models were simulated under representative indoor ventilation and occupancy conditions. The objective of the present study is to investigate the effect of CO 2 sensor position on the performance of DCV systems under mixing and displacement ventilation. CO 2 concentration may vary within an occupied space and it is unclear how sensor location influences the ventilation and energy performances. CO 2-based demand controlled ventilation (DCV) can save energy while maintaining acceptable indoor air quality.